منابع مشابه
β-glucans and cholesterol (Review)
Hypercholesterolemia is one of primary risk factors of cardiovascular disease, together with metabolic syndrome, hypertension and diabetes. Although progress has been made, the search for novel methods of preventing and treating dyslipidemia is ongoing and current therapies for cardiovascular disease induce various side effects. β‑glucans are linear unbranched polysaccharides found in various n...
متن کاملCholesterol depletion using methyl-β-cyclodextrin.
Cholesterol is an essential component of mammalian cells. It is the major lipid constituent of the plasma membrane and is also abundant in most other organelle membranes. In the plasma membrane cholesterol plays critical physical roles in the maintenance of membrane fluidity and membrane permeability. It is also important for membrane trafficking, cell signalling, and lipid as well as protein s...
متن کاملCholesterol modulates the dimer interface of the β₂-adrenergic receptor via cholesterol occupancy sites.
The β2-adrenergic receptor is an important member of the G-protein-coupled receptor (GPCR) superfamily, whose stability and function are modulated by membrane cholesterol. The recent high-resolution crystal structure of the β2-adrenergic receptor revealed the presence of possible cholesterol-binding sites in the receptor. However, the functional relevance of cholesterol binding to the receptor ...
متن کاملCholesterol-Independent Effects of Methyl-β-Cyclodextrin on Chemical Synapses
The cholesterol chelating agent, methyl-β-cyclodextrin (MβCD), alters synaptic function in many systems. At crayfish neuromuscular junctions, MβCD is reported to reduce excitatory junctional potentials (EJPs) by impairing impulse propagation to synaptic terminals, and to have no postsynaptic effects. We examined the degree to which physiological effects of MβCD correlate with its ability to red...
متن کاملFluorescent detection of cholesterol using β-cyclodextrin functionalized graphene.
A fluorescence based cholesterol detection method has been developed using competitive host-guest interaction between graphene bound β-cyclodextrin (β-CD) with rhodamine 6G (R6G) and cholesterol. Fluorescence of β-CD incorporated R6G is quenched by graphene but is 'turned on' by cholesterol as it replaces R6G from the β-CD host.
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1936
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)74745-5